4 edition of Drug metabolism found in the catalog.
|Statement||edited by N.J. Gooderham.|
|Series||Biomedical and health research -- v.25.|
|The Physical Object|
|Pagination||viii, 213 p. :|
|Number of Pages||213|
|ISBN 10||9051993781, 4274901939|
|LC Control Number||97075198|
A valuable reference tool for professionals involved in the industry, Drug Metabolism in Pharmaceuticals covers new tools such as LC-MS and LC-MS-NMR along with experimental aspects of drug metabolism. This work fills a gap in the literature by covering the concepts and applications of pharmaceutical research, development, and assessment from the point of view of drug metabolism. Current Drug Metabolism aims to cover all the latest and outstanding developments in drug metabolism and disposition. The journal serves as an international forum for the publication of timely reviews and guest edited issues in drug metabolism. Current Drug Metabolism is an essential journal for academic, clinical, government and pharmaceutical.
- an important modulator of intestinal drug transport and usually functions to expel drugs from the intestinal mucosa into the lumen, thus contributing to presystemic elimination. - P-gp and other members of the MDR family are also found in the blood-brain barrier and in drug-resistant cancer cells. Book Description Springer Apr , Taschenbuch. Condition: Neu. Neuware - The Drug Metabolism and Pharmacokinetics, Quick Guide covers a number of aspects of drug assessment at drug discovery and development stages, topics such as pharmacokinetics, absorption, metabolism, enzyme kinetics, drug transporters, drug interactions, drug-like properties, assays and in silico calculations/5(2).
The term 'drug metabolism' in its broadest sense may be considered as the absorption, distribution, biotransformation and excretion of drugs. To cover all these facets of drug metabolism in a single text is a voluminous task and therefore we have focused primarily on the biotransformation aspects of the subject. Feb 22, · In the intestine for example, several drug metabolising enzymes are presumed to decrease the bioavailability of orally administered drugs or to activate environmental carcinogens. Phase II of metabolism may or may not be preceded by Phase I reactions. Phase II enzymes undoubtedly play an important role in the detoxification of various shareholderdemocracy.com by: 5.
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Factors affecting drug metabolism, such as genetic polymorphisms, age and diet are discussed and how metabolism can lead to toxicity is explained.
The book concludes with the role of drug metabolism in the commercial development of therapeutic agents as well as the pharmacology of some illicit drugs.
Online shopping from a great selection at Books Store. Handbook of Drug Metabolism, Third Edition (Drugs and the Pharmaceutical Sciences). Recently, he identified and patented pharmacologically active metabolites of Nexavar®.
Nassar serves on the Editorial Board of Drug Metabolism Letters and The Open Drug Metabolism Journal and is also a reviewer for several other journals. Drug-drug interactions and adverse reactions Strategies for drug design. This book is ideally suited as an advanced text for courses in drug metabolism for students of medicine, pharmacy, pharmacology, biochemistry; and for courses in drug design and drug delivery for students of medicinal chemistry.
between drug structure and metabolism, as well as providing examples of how metabolic stability studies have contributed to the design of drugs with improved bioavailabilities and favourable half-lives.
In the final chapter of this book dealing with drug design, we return to this topic and. Explains All The Latest Tools And Technologies In Drug Metabolism. Drug Metabolism Handbook is dedicated to helping bench scientists take full advantage of the latest and most advanced tools and techniques in the field of drug metabolism.
From creating new molecular entities to drug development to troubleshooting, the book explains the concepts of drug metabolism and guides readers through Cited by: Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism.
The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states. In the fields of medicine, drug discovery is the process by which new candidate medications are discovered.
This book demonstrates that various expertise are essential for drug discovery including synthetic or natural drugs, clinical pharmacology, receptor identification, drug metabolism, pharmacodynamic and pharmacokinetic research. Drug metabolism is the metabolic breakdown of drugs by living organisms, usually through specialized enzymatic systems.
More generally, xenobiotic metabolism (from the Greek xenos "stranger" and biotic "related to living beings") is the set of metabolic pathways that modify the chemical structure of xenobiotics, which are compounds foreign to an organism's normal biochemistry, such as any drug.
Jul 25, · It is almost a decade since the second edition of the Handbook of Drug Metabolism was published. Since its inception, the goal of the Handbook was to provide a comprehensive text to serve as a graduate course in Drug Metabolism, a useful reference for academic and industrial drug metabolism scientists, but also as an important reference tool for those pursuing a career in drug discovery and.
Drug Metabolism in Diseases is a comprehensive reference devoted to the current state of research on the impact of various disease states on drug metabolism. The book contains valuable insights into mechanistic effects and examples of how to accurately predict drug metabolism during these different pathophysiological states.5/5.
Human Drug Metabolism book. Read 2 reviews from the world's largest community for readers. Drug metabolism is a core area of pharmacology. Before any dru /5. This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments.
It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabol.
Drug Metabolism. Drug metabolism is an immense area of study where drugs undergo a range of enzyme-mediated chemical reactions, such as oxidation. Dec 01, · DMD presents important research in pharmacology and toxicology and is a valuable resource in drug design, drug metabolism, drug transport, expression of drug metabolizing enzymes and transporters, and regulation of drug metabolizing enzyme and transporter gene expression.
Drug Metabolism and Pharmacokinetics Quick Guide is intended for broad readership of those interested in the discipline of drug metabolism and pharmacokinetics who work in drug discovery coming from the various disciplines, a background such as of medicinal chemistry, pharmacology, drug metabolism and pharmacokinetics, bioanalysis, clinical sciences, biochemistry, pharmaceutics or toxicology.
The liver plays a central role in metabolism of nutrients, synthesis of glucose and lipids, and detoxification of drugs and xenobiotics. The major pathways in the liver are glucose, fatty acids. Drug metabolism rates vary among patients. Some patients metabolize a drug so rapidly that therapeutically effective blood and tissue concentrations are not reached; in others, metabolism may be so slow that usual doses have toxic effects.
Individual drug metabolism rates are influenced by genetic factors, coexisting disorders (particularly. Drug Metabolism and Pharmacokinetics (DMPK) is an official online journal of the Japanese Society for the Study of Xenobiotics (JSSX), and it replaces the JSSX's former journal, Xenobiotic Metabolism and Disposition.
The journal will accept original submissions in English on the understanding that the work is unpublished and is not being considered for publication elsewhere. May 20, · This book continues to be the definitive reference on drug metabolism with an emphasis on new scientific and regulatory developments.
It has been updated based on developments that have occurred in the last 5 years, with new chapters on large molecules disposition, stereo-selectivity in drug metabolism, drug transporters and metabolic activation of shareholderdemocracy.com by: 1. Dec 24, · Synopsis Provides a timely update to a key textbook on human drug metabolism The third edition of this comprehensive book covers basic concepts of teaching drug metabolism, starting from extreme clinical consequences to systems and mechanisms and shareholderdemocracy.com: Michael D.
Coleman.This new volume of Advances in Pharmacology explores the current concepts in drug metabolism and toxicology. Chapters cover the Keap1-Nrf2 cell defense pathway, animal models of drug-induced idiosyncratic toxicity and the use of human embryonic and induced pluripotent stem cells for modeling metabolism and toxicity.Mar 29, · A source of expertise for a rapidly changing and expanding field, the book provides a framework for drug metabolism in drug discovery and development.
Containing tables, drawings, photographs, and equations, it highlights the importance of pharmacokinetics and cytochrome P, explains clearance, volume of distribution, sequential metabolism Cited by: